The Fred Hutchinson Cancer Research Center is located in Seattle, Washington. Our mission is to eliminate cancer as a cause of human suffering and death.

Quantitative Genetic Epidemiology
Introduction

Mission

Members

Software Downloads

Papers

Contact QGE 		Home / Papers

Papers

Published

  1. Guo ZR, Lu JH, Zhao LP, Zhang SG. Schistosomasis Japonicum and colon cancer-An inquiry about the pathogenesis of colon cancer by using logistic regression model. Sina Academy of Epidemiology 1987; 8: 21-24.
  2. Guo ZR, Zhao LP. Genetic Etiology of Colon Cancer. Hereditas 1989; 11: 26-30.
  3. Breslow N, Zhao LP. Logistic regression for stratified case-control studies, Biometrics l988; 44: 89l-899.
  4. Zhao LP, Prentice R. Correlated binary regression using a quadratic exponential model. Biometrika l990; 77: 642-48.
  5. Zhao LP, Thompson E, Prentice R. Joint estimation of recombination fraction and interference coefficient in multilocus linkage analysis. Am J Human Genetics l990; 47: 255-65.
  6. Prentice R, Zhao LP. Oral contraceptive and disease risk. Encyclopedia of Human Biology 1991, New York: Academic Press Inc.
  7. Prentice R, Zhao LP. Estimating equations for parameters in means and covariance. Biometrics 1991; 47: 825-839.
  8. Zhao LP, Kushi L, Klein R, Prentice R. Quantitative review of studies of dietary fat and rat colon carcinoma. Nutrition and Cancer 1991; 15:169-177.
  9. Zhao LP, Prentice R. Use of a quadratic exponential model to generate estimating equations for means, variances and covariances in Estimating Equations (VF Godambe, ed.), Oxford: Oxford University Press, 1991.
  10. Zhao LP, Prentice R, Self S. Multivariate mean parameter estimation by using a partly exponential model. JRSS (B) 1992; 54: 805-811.
  11. Hankin J, Zhao LP, Wilkens L, Kolonel L. Attributable risks of breast, prostate and lung cancer due to saturated fat in Hawaii. Cancer Causes and Control 1992; 3: 17-23.
  12. Zhao LP, Grove J, Quiaoit F. A method for assessing patterns of familial resemblance in complex human pedigrees with an application to the nevus count data in Utah Kindreds. Am J Human Genet 1992; 51: 178-190.
  13. Zhao LP, Kolonel L. Efficiency loss from categorizing quantitative into qualitative exposures in case-control studies. Am J Epi 1992; 136: 464-474.
  14. Zhao LP, LeMarchand L. An Analytic method for assessing patterns of familial aggregation in case-control studies. Genet Epidemiol 1992; 9: 141-154.
  15. Zhao LP, Lipsitz S. Design and analysis of two-stage studies. Statistics in Medicine 1992; 11: 769-782.
  16. Grove J, Zhao LP, Quiaoit F. Correlation analysis of twin data with repeated measures based on generalized estimating equations. Genet Epi. 1993; 10: 539-544.
  17. Kolonel LN, LeMarchand L, Hankin, Nomura AMY, Goodman MT, Wilkens LR, Zhao LP. Case-control studies on vitamins and cancer in a multiethnic population. IN Vitamins and Cancer Prevention, Pennington Center Nutrition Series, edited by Bray GA, Ryan DH. Baton Rough: Louisiana State University Press, 1993.
  18. LeMarchand L, Hankin JH, Kolonel LN, Beecher GR, Wilkens LR, Zhao LP. Intake of specific carotenoids and lung cancer risk. Cancer Epidemiology and Biological Marker for Cancer Prevention 1993; 2: 183-187.
  19. Zhao LP, Grove J, Quiaoit F. Empirical evaluation of the sampling plan used in a study of LDL subclass pattern. Genet Epi. 1993; 10: 635-640.
  20. Zhao LP, Haile R, Grove J, LeMarchand L. RE: Control for environmental risk factors in assessing genetic effects on disease familial aggregation. Am J Epi 1993; 137: 257-259.
  21. Lipsitz SR, Kim K, Zhao LP. Analysis of repeated categorical data using generalized estimating equations. Statistics in Medicine 1994; 13: 1149-1163.
  22. Zhao LP. Segregation analysis of human pedigrees using estimating equations. Biometrika 1994; 81: 197-209.
  23. Robins J, Rotnitzky A, Zhao LP. Estimation of regression coefficients when some regressors are not always observed. JASA 1994; 89: 846-866.
  24. Lipsitz, SR, Dear KB, Zhao LP. Jacknife estimators of variance for parameter estimates from estimating equations with application to clustered survival data. Biometrics 1994; 50: 842-846.
  25. Lipsitz SR, Zhao LP. Estimation in contingency table with given marginals. The Statistician 1994; 43: 223-230.
  26. Robins J, Rotnitzky A, Zhao LP. Analysis of semiparametric regression models for repeated outcomes under the presence of missing data. JASA 1995; 90: 106-121.
  27. Lipsitz SR, Fitzmaurice GM, Sleeper L, Zhao LP. Estimation method for the joint distribution of repeated binary observations. Biometrics 1995; 51: 562-570.
  28. Zhao LP, Grove J. Identifiability of Segregation Parameters Using Estimating Equations. Human Heredity 1995; 45: 286-300.
  29. Hsu L, Zhao LP. Assessing familial aggregation of age-of-onset using estimating equations; with application to breast cancer. Am J Hum Genet 1996; 58: 1057-1071.
  30. Liu SL, Rodrigo AG, Shankarappa R, Learn GH, Hsu L, Davidov O, Zhao LP, Mullins JI. HIV quasispecies and resampling (letter). Science 1996; 273: 415-416.
  31. Zhao LP, Kristal AR, White E. Estimating relative risk function in case-control studies using a nonparametric logistic regression. Am J Epidemiology 1996; 144: 598-609.
  32. Zhao LP, Lipsitz S, Lew D. Regression analysis with missing covariate data using estimating equations. Biometrics 1996; 52: 1165-1182.
  33. LeMarchand L, Zhao LP, Quiaoit F, Wilken L, Kolonel N. Family history and risk of colorectal cancer. Am J Epidemiology 1996; 144: 1122-1128.
  34. Wang CY, Wang S, Zhao LP, OU ST. Weighted semiparametric estimation in regression analysis with covariate data. JASA 1997; 92: 512-525.
  35. Zhao LP, Hsu L, Davidov O, Potter J, Elston R, Prentice RL. Population-based family study designs: an interdisciplinary research framework for genetic epidemiology. Genetic Epidemiology 1997; 14: 365-388.
  36. Xu Z, Zhao LP, Malone K, Prentice RL. Oral Contraceptive and Disease Risk. Encyclopedia of Human Biology, New York: Academic Press Inc., 1997.
  37. Holte S, Quiaoit F, Hsu L, Davidov O, Zhao LP. A population-based family study of a common oligogenic disease (I): Association/Aggregation Analysis. Genetic Epidemiology 1997; 14: 803-807
  38. Zhao LP, Quiaoit F, Hsu L, Davidov O, Holte S. A population-based family study of a common oligogenic disease (II): The segregation analysis. Genetic Epidemiology 1997; 14: 945-949
  39. Zhao LP, Kristal AR, White E. RE: Estimating relative risk function in case-control studies using a nonparametric logistic regression. Am J Epidemiology 1997; 146: 882-885.
  40. Zhao LP, Quiaoit F, Hsu L, Aragaki C. An efficient, robust and unified framework for mapping complex traits (I): Two-point linkage analysis. American Journal of Medical Genetics 1998; 77: 366-383.
  41. Zhao LP, Aragaki C, Hsu L, Quiaoit F. Mapping complex traits with single nucleotide polymorphism. American Journal of Human Genetics 1998; 63: 225-240.
  42. Zhao LP, Quiaoit F, Aragaki C, Hsu L. An efficient, robust and unified framework for mapping complex traits (II): Multipoint linkage analysis. American Journal of Medical Genetics 1998; 79:48-61.
  43. Zhao LP, Hsu L, Holte S, Chen Y, Quiaoit F, Prentice RL. Combined association and aggregation analysis of case-control family data. Biometrika 1998; 85: 229-315.
  44. Zarbl H, Aragaki C, Zhao LP. An efficient protocol for rare mutation genotyping in a large population. Genetic Testing 1999; 2: 315-321.
  45. Zhao LP, Quiaoit F, Aragaki C, Hsu L. An efficient, robust and unified framework for mapping complex traits (III): Combined linkage/linkage-disequilibrium analysis. American Journal of Medical Genetics 1999; 84: 433-453.
  46. Zhao LP, Prentice RL, Shen F, Hsu L. On the assessment of statistical significance in disease gene discovery. American Journal of Human Genetics 1999; 64: 1739-1753.
  47. Lipsitz SR, Ibrahim JG, Zhao LP. A weighted estimating equation for missing covariate data with properties similar to maximum likelihood. American Journal of Statistical Association 1999; 94: 1147-1160.
  48. Hsu L, Prentice RL, Zhao LP, Fan J. On dependence estimation using correlated failure time data from case-control family studies. Biometrika 1999; 86: 743-753
  49. Zhao LP, Aragaki C, Hsu L, Potter J, Elston R, Malone K, Daling J, Prentice R. Integrated designs for gene discovery and characterization. JNCI 1999; 26: 71-80
  50. Aragaki C, Quiaoit F, Hsu L, Zhao LP. Mapping alcoholism genes using linkage/linkage-disequilibrium analysis. Genetic Epidemiology, 1999;17 Suppl 1:S43-8.
  51. Hsu L, Aragaki C, Quiaoit F, Wang X, Xu X, Zhao LP. A genome wide scan of SM disease using two newly developed methods. Genetic Epidemiology 1999;17 Suppl 1:S621-6.
  52. Hsu L, Zhao LP, Malone K, Daling J. Genetic anticipation in breast cancer using survival analysis method. Genetic Epidemiology 2000; 18: 17-32.
  53. Hsu L, Zhao LP, Aragaki C. A note on a conditional likelihood approach for family-based association studies of candidate genes. Human Heredity 2000; 50: 194-200
  54. Zhao LP, Zarbl H. Single Nucleotide Polymorphisms and Future Applications (p117-138) in SNP and Microsatellite Genotyping: Markers for genetic analysis, edited by A. Hajeer, J. Worthington and S. John. Eaton Publishing, 2000.
  55. Zhao LP, Prentice RL, Breeden L. Statistical modeling of large microarray data sets to identify stiumulus-response profiles. Proceedings of National Academic Sciences 2001, 98, 5631-5636
  56. Thomas JG, Olson JM, Tapscott SJ, Zhao LP. An efficient and robust statistical modeling approach to analyze genome-wide expression profiles: discovery of differentially expressed genes in human cancers. Genome Research 2001, 11:1227-1236
  57. Bergemann T, Quiaot F, Delrow, Zhao LP. Statistical issues in signal extraction from microarrays. Proceedings of SPIE 2001, 2, 24-33.
  58. Hsu L, Prentice RL, Zhao LP, Li S (2001) Incorporating ages at onset information into the Transmission/Disequilibrium test. Genetic Epidemiology, 21: 347--353.
  59. Dewanji A, Zhao LP. An optimal estimating equation with unspecified variances. Sankhya: The Indian Journal of Statistics 2002, 64, 95-108.
  60. Xu L, Olson J, Zhao LP. A Regression-Based Method for Genomewide Time Course Study and its Application to Discover Differentially Expressed Genes in an Inducible Huntington's Disease Transgenic Model. Human Molecular Biology, 2002, 11, 1977-1985
  61. Zhao LP. Is statistical significance still significant in the post genome era? ICSA Bulletin, 2002
  62. Zhao LP, Davidov O, Quiaoit F, Hsu L, Holte S. Combined association, segregation and aggregation analysis on case-control family data. Biostatistics 3, 315-329, 2002
  63. Méndez E, Cheng C, Farwell DG, Agoff SN, Futran ND, Weymuller EA, Jr., Maronian NC, Zhao LP and Chen C. Transcriptional Expression Profiles of Oral Squamous Cell Carcinomas. Cancer 95: 1482-1494, 2002.
  64. Zhao LP, Li S and Khalid N. Assessing Haplotype-Based Association with Multiple SNPs in Case-Control Studies. American Journal of Human Genetics 72, 1231-1250, 2003

In Press

  • Hsu L, Zhao LP, Li H. Genetic analysis of censored ages at onset from population based family studies. Biometrika
  • Hsu L, Prentice RL, Zhao LP, Li S. Incorporating ages at onset information into the transmission/disequilibrium test. Genetic Epidemiology
  • Li S, Khalid N and Zhao LP. Estimating Haplotype Frequencies and Standard Errors for Multiple Single Nucleotide Polymorphisms. Biostatistics
  • Cheng C, Kimmel B, Neiman P and Zhao LP. Array rank order regression analysis to detect gene copy-number changes. Genomics
  • Kyle A. Serikawa, Xie Lillian Xu, Vivian MacKay, G. Lynn Law, Qin Zong, Zhao LP, Roger Bumgarner and David Morris. The transcriptome and its translation during the recovery from cell-cycle arrest in Saccharomyces cerevisiae.
  • Laws R.J., Bergemann TL, Quiaoit F, Zhao LP. SignalViewer: analyzing microarray images. Bioinformatics
  • Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Najma Khalid, Dan R. Hare, Paula A. Ladne, Olga Sala-Tora, LP Zhao, and Jerald P. Radich. Single-Stranded Linear Amplification Protocol ("SLAP") Results in Reproducible and Reliable Microarray Data from Nanogram Amounts of Starting RNA. Genomics

Submitted Manuscripts

  • Olson JM, Strand A, Gromier M, Zhao LP, Geyer JR, Ellenbogen R, Biegel J and Tapscott SJ. Distinct gene expression in subsets of medulloblastomas suggest tumor-specific therapies.
  • Yang S, Hsu L, Zhao LP. Combining two asymptotically normal test statistics.
  • Neely WW and Zhao LP. Analysis of gene expression data from case-control studies using heterogeneous logistic regression models.
  • Zhao LP, Neely WW and Li X. E-Diagnosis using GeneChip Technology.
  • Robert Kimmel, Chun Cheng, LP Zhao, R. Michael Tuttle, Kenneth J. Kopecky, Doan Nguyen, Somnit Lee, Mark Aronszajn, Vladimir P. Troshin, Anatoli F. Tsyb, Jeffrey Delrow, Scott Davis, Paul Neiman, High Rates of Gene Amplification Occur in Post-Chernobyl Thyroid Cancer
  • Vivian L. MacKay, Xiaohong Li, Kyle A. Serikawa, X. L. Xu, G. Lynn Law, Lue Ping Zhao, and David R. Morris. Translating a transcriptome: qualitative and quantitative diversity among individual messenger RNA species.
  • Zhao LP, Neely WW. A statistical framework for building predictive models using expression array technology
  • Xiaohong Li, Eric Fung, Scott Weinberg, Bao-Ling Adam, John W. Davis, John Semmes, George L. Wright Jr. and LP Zhao. A Statistical Approach for Analyzing ProteinChip Data and its Application to Prostate Cancer Data Analysis